I have a distributor that is about a 40 minute drive away. My cost, per box, is usually $5.00 over his cost, plus shipping.
Of course I do visit the local card shop, but his prices are usually $30-$50 over his cost. It should be noted though that, unlike my distributor, the LCS has to purchase from a distributor, pay for shipping, and needs a substantial markup to pay for overhead. (example: 2014 Total Memorabilia... my cost through my distributor - $90.00 / cost through the LCS - $125.00)