I've gone back to school so many times, I literally started to feel dumber as if it was starting to have the opposite effect. That said, here are some lessons I learned (and continue to learn):
1) Figure out what kind of job you would love to do even if you didn't get paid for it. Pursue a degree that will help you obtain that job.
2) Be prepared to change your mind and your major anywhere from 1-14 times, depending on how much your mood and environment changes.
3) If you're interested in a major but not sure if it's for you, try to sneak in an elective in that field. If after that term you still love it, jump on it!
When I was fresh out of high school, I wanted to major in Sociology. That changed to Public Relations. That changed to Nursing. That changed to Social Work. I haven't been in school in many years but if and when I go back, if you were to ask me today, I'd probably pursue Human Resources. During each of these points in my life, I was in a different place. Different things were going on that were pointing me in different directions. This is a lesson on how not to do it because here I am at my age without a degree. lol
Wait ... that statement just basically told you to ignore everything I've said so far. Hmmmm
Stay in school.
*edit* Oh one more thing. If you think you want to live somewhere else, research the job markets in that place. There's nothing worse than pursuing a degree and then going somewhere where that degree doesn't help much in your job hunt.